RohrS.Roleofgapjunctionsinthepropagationofthecardiacactionpotential[J].CardiovascularResearch,,62(2):-
Abstract：Gapjunctionsplayapivotalroleforthevelocityandthesafetyofimpulsepropagationincardiactissue.Underphysiologicconditions,thespecificsubcellulardistributionofgapjunctionstogetherwiththetightpackageingoftherod-shapedcardiomyocytesunderliesanisotropicconduction,whichiscontinuousatthemacroscopicscale.However,whenbreakingdownthethree-dimensionalnetworkofcellsintolinearsinglecellchains,gapjunctionscanbeshowntolimitaxialcurrentflowandtoinduce‘saltatory’conductionatunchangedoverallconductionvelocities.Intwo-andthree-dimensionaltissue,thesediscontinuitiesdisappearduetolateralaveragingofdepolarizingcurrentflowattheactivationwavefront.Duringgapjunctionaluncoupling,discontinuitiesreappearandareac北京哪些医院白癜风好合肥最好的白癜风医院
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